All membrane fusion reactions proceed through an initial fusion pore. including calcium-triggered release of neurotransmitters and hormones. Expansion of this small pore to release cargo is energetically costly and regulated by cells. but the mechanisms are poorly understood. https://allfixelectricales.shop/product-category/vinyl-record-cleaning-brush/
The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores
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