In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions. a c-di-GMP phosphodiesterase (PDE) RapA is expressed. depleting cellular c-di-GMP and causing the loss of a critical outer-membrane adhesin LapA from the cell surface. https://parisnaturalfoodes.shop/product-category/platinum-100-beta-alanine/
A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage.
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