Abstract Mutations that decrease or increase the activity of the tyrosine phosphatase. SHP2 (encoded by PTPN11). promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of an epigenetic enzyme; upon phosphorylation by the kinase ACK1/TNK2. https://themightyhobbyers.shop/product-category/dorbz/