DNA evolution models made invaluable contributions to comparative genomics. although it seemed formidable to include non-genomic features into these models. In order to build an evolutionary model of transcription networks (TNs). we had to forfeit the substitution model used in DNA evolution and to start from modeling the evolution of the regulatory relationships. https://www.roneverhart.com/SAAB-9-3-I-98-02-Frontlykt-Hoyre/